منابع مشابه
Therapeutic hypothermia: neuroprotective mechanisms.
Hypothermia has long been known to be a potent putative neuroprotectant. Experimental evidence and clinical experience show that hypothermia protects the brain from cerebral injury. Recent insights into the mechanisms of cerebral ischemia and reperfusion suggest reasons why hypothermia may be an ideal modality for stroke therapy. Hypothermia protects brain tissue in multiple ways. It retards en...
متن کاملNeuroprotective effects of deep hypothermia in refractory status epilepticus
OBJECTIVE Pharmacoresistance develops quickly during repetitive seizures, and refractory status epilepticus (RSE) remains a therapeutic challenge. The outcome of RSE is poor, with high mortality and morbidity. New treatments are needed. Deep hypothermia (20°C) is used clinically during reconstructive cardiac surgery and neurosurgery, and has proved safe and effective in those indications. We te...
متن کاملSynergistic neuroprotective therapies with hypothermia.
Neuroprotection is a major health care priority, given the enormous burden of human suffering and financial cost caused by perinatal brain damage. With the advent of hypothermia as therapy for term hypoxic-ischemic encephalopathy, there is hope for repair and protection of the brain after a profound neonatal insult. However, it is clear from the published clinical trials and animal studies that...
متن کاملEffects of Methylprednisolone on Neuroprotective Effects of Delay Hypothermia on Spinal Cord Injury in Rat
STUDY DESIGN A retrospective study. PURPOSE The aim of this study was to evaluate the effects of delayed hypothermia on spinal cord injuries in rats. In addition, the effect of methylprednisolone on therapeutic window of hypothermia was evaluated. OVERVIEW OF LITERATURE Several studies have demonstrated that early hypothermia is the most effective neuroprotective modality. However, delayed ...
متن کاملTreatment temperature and insult severity influence the neuroprotective effects of therapeutic hypothermia.
Therapeutic hypothermia (HT) is standard care for moderate and severe neonatal hypoxic-ischaemic encephalopathy (HIE), the leading cause of permanent brain injury in term newborns. However, the optimal temperature for HT is still unknown, and few preclinical studies have compared multiple HT treatment temperatures. Additionally, HT may not benefit infants with severe encephalopathy. In a neonat...
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ژورنال
عنوان ژورنال: Nihon Shuchu Chiryo Igakukai zasshi
سال: 1997
ISSN: 1340-7988,1882-966X
DOI: 10.3918/jsicm.4.11